Chimeric antigen receptor T cell (CAR-T) therapies are an exciting new field of biologics drug discovery. These therapies target various forms of cancer, acting as a “living therapeutic”. By utilizing a patient’s own T lymphocyte cells they realize the potential of personalized medicine.
CARs are artificial receptor proteins, composed of mostly naturally-occurring subdomains. Scientists working on these therapies often encounter challenges in managing their laboratory data.
Accurately defining the proteins and capturing their full description, including sophisticated control mechanisms to avoid unwanted side effects such as cytokine storms, is critical for robust intellectual property (IP) protection. Tracking relationships between subdomains and related entities is also essential but difficult to achieve. Supporting the complex laboratory workflows used to create the subdomains and whole proteins requires both flexibility and standardization. And once data about the candidates are available, scientists need to see it all, and in real time, to make well-informed decisions.
Development of the CARs requires iterations of experiment development and execution. As the project evolves, your experiments transition from mostly ad hoc to standardized workflows.
A CAR research project will result in many candidate molecules. You derive these from a variety of precursor proteins. It’s important for you to track the relationships among the CARs and their subdomains. And that information should be available to you, at any time.
You design novel CARs to have the right combination of antigen-binding and cellular response. Your scientific innovations are valuable, and need rigorous protection.
Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides, plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics Browser provides a comprehensive view of project data
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
Mobile technology offers a unique opportunity to collaborate, access data and make decisions on the go, increasing throughput and reducing time consumed by review processes. The Dotmatics Platform on the cloud allows the integration of multiple, diverse systems and data sources. Organizations can now securely access all of the Dotmatics solutions, using a web browser, on their own dedicated instance running in the cloud. This provides users with an all-encompassing view of relevant information, enabling better informed science and business decisions.The Dotmatics Platform in the cloud is powered by Amazon Web Services™ (AWS). Data security is guaranteed when using the gold standard AWS infrastructure. Dotmatics’ solutions are installed in Amazon-controlled data centers around the world thus ensuring that data is housed at the user’s preferred location. The Dotmatics Platform provides a single point of access to all science data and functions across multidisciplinary groups. The flexibility enables scientists, collaborators and partners to instantly interact with the same data via the cloud regardless of location and time zone, fulfilling the promise of real time research.
At the heart of collaborative research
Protect and control your database with single tenancy
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