A discovery project crosses departments, scientific disciplines, physical locations and sometimes companies. Requests, data and results need to flow seamlessly between all members to ensure the efficient execution of the project.
Every member of the project team needs real-time access to all the project data for which they have permission, irrespective of where it is stored. This ensures that they can make the best-informed decisions about project progression.
Increasing efficiency will reduce discovery cycle times. This can be achieved with seamless integrated data workflows that mirror each scientist’s lab workflow, by the automation of data flows from instruments and by cross-functional workflows that span diverse team members.
Biologics discovery and development workflows are complex, highly iterative and requires many handoffs between different scientific teams within a company or across collaborating organizations.
Dotmatics provides a comprehensive solution that maps on to all stages of a discovery workflow, such as the antibody discovery workflow shown (also see the Dotmatics Antibody Discovery solution). The workflows leverage applications in the Dotmatics portfolio including a biologics-enabled electronic lab notebook (BioELN), biological registration, inventory management, assay data management, work request system, search, and visual data analytics. All Dotmatics capabilities are fully integrated allowing them to adapt seamlessly to a scientist’s workflows. For example, from the BioELN interface, a new entity in the biological registration system can be created with a single click. Scientists and managers can use the work-request system to create and monitor cross-team workflows. Dashboards allow all team members to monitor the status of project and their workflows.
Integrated workflows, created with biologics-specific ELN templates, allow molecular biologists to capture their experiments in the BioELN and send the data directly to Bioregister. Bioregister is the system of record that captures the full breadth of scientific datatypes that are being investigated as candidate therapeutics or used as part of the discovery process. These include DNA, RNA, proteins, antibodies, antibody-drug conjugates, plasmids, chemically-modified peptides and nucleotides, cell lines, as well as new, user-defined entities. Bioregister captures not only the entities and their attributes but also relationships between those entities. It also enables users to record sample, clone, vector, purification and expression information and to manage the protein production process. Once samples are available, scientists use Cascade to request assay services on them. Entities stored in Bioregister can be accessed directly in the BioELN, simplifying workflows.
Integrated workflows in Inventory allow sample managers to receive biologic (and other) samples into a hierarchy of storage locations, manage sample lifecycles, and distribute aliquots and plates for testing. RESTful web services within the Dotmatics platform means many capabilities of Inventory can be accessed directly from the BioELN, so the end-user scientist does not need to change user interface, streamlining their workflows.
Integrated workflows allow assay scientists to capture and analyze data from primary, secondary and DMPK assays in Studies. Advanced visual and statistical analysis of assays is also available in Vortex.
They can publish validated assay results directly to the scientific teams.
They can use Cascade to request samples and plates from inventory management.
Studies uses the same underlying framework as the BioELN, reducing the user-interface learning curve for end-user scientists.
All team members can use Browser to search across all research data including experiments, sequences and other biologic entities, samples and assays as soon as BioELN experiments are published and results become available.
Vortex provides bioinformatics analysis in an easy to use graphical interface that allows a wide range of scientists to undertake analyses without having to write scripts. Available methods including sequence alignment and clustering, a range of methods to assess relationships between sequence and activity and to build predictive models of those, as well as statistical analysis and high-performance visualization of project data. These capabilities allow the team to make timely, well-informed decisions about project progressions.
Real-time dashboards support project management decision making.
Dotmatics software is designed for collaboration between scientific teams within an organization or, when cloud hosted, across a collaborative research network of pharmas, biotechs, CROs and academic labs. Experiments in the BioELN and published scientific data can be shared in real time, event feeds and dashboards show up-to-date project status and collaboration and communication tools facilitate interaction between distributed teams.
Dotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides, plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.