Antibodies are a leading class of drugs on the market, providing treatment options for many diseases. Alongside conventional forms, there are now engineered versions, such as bi- and tri-specifics, antibody-drug conjugates, and fusion proteins.
This rich landscape offers many opportunities for innovation. At the same time, it brings challenges in managing and interpreting your data. The Dotmatics solution for antibody discovery supports your science and streamlines experiments.
Antibody discovery involves common workflows, such as immunization protocols and protein production workflows. But it also requires scientific innovation to refine candidates and tune them to be safe and effective.
Antibody discovery projects generate large volumes of diverse data. This creates challenges in managing the data, especially tracking relationships between candidates. Viewing all project data in context is critical for informed decision-making.
Competition in the drug discovery industry is fierce. Many companies are targeting the same therapeutic areas. Scientific innovation in antibody design and experimental processes are valuable assets. They need rigorous protection.
Capture experimental dataThe Dotmatics solution provides experiment data capture that meets the needs of scientists. Typical workflows such as immunization protocols and protein production workflows are available. But sometimes more ad hoc investigations are needed to explore new science. The Dotmatics solution supports this innovation as well. Digital capture ensures the highest quality of data, allowing research to progress rapidly. Studies Notebook, Dotmatics’ electronic laboratory notebook (ELN), manages this process.
View all project data, at any timeInterpreting data and making well-informed decisions requires that you can see a complete picture of your antibody data. Dotmatics Browser makes this possible by bringing the information you need in a view that makes sense to you. You can easily search and browse the results, allowing you to apply your scientific expertise. With Dotmatics Vortex you can see heavy and light chain sequences annotated with CDRs and other important motifs. You can do “what-if” experiments to test the effects of mutations as you optimize your candidates.
Register entities, track relationships, protect intellectual propertyAntibody discovery involves finding the right combination of optimized heavy and light chains. It’s a race to find the right therapeutic amongst fierce competition. This research creates a comprehensive set of relationships representing your scientific innovation. That science, and the value it represents, is protected by Dotmatics Bioregister. This ensures the organizations’ intellectual property (IP) rigorously protected without limiting access to the data for your scientists.
Dotmatics BrowserDotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.
Dotmatics Studies NotebookDotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics BioregisterDotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides, plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.
Dotmatics PlatformThe Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics VortexDotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
Dotmatics StudiesDotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics PlatformThe Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics InventoryDotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics CascadeDotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
