Today’s research projects are often carried out across collaborative networks of pharma, biotechs, CROs and academics. Projects vary from fee-for-service to joint IP discovery to large consortia. Many companies have made large investments in these projects but face challenges optimizing information flow across the network. Too often work requesting and results sharing are manual, using email, file shares and reports. This can lead to lengthy delays in turn-around time, as well as errors in data transcription and interpretation. This slows innovation and adversely impacts the expected return on investment of the move to external collaboration.
The Dotmatics solution for collaborative network research can help ensure success whatever the externalized project. It provides real-time scientific data exchange, informed project management and, when appropriate, shared scientific decision making across the partners.
Every project should have a single source of truth for scientific project data. Every member of the project team should have access to all the data for which they have permission, irrespective of which partner generated it. This ensures that they can make the best-informed decisions about project progression.
Requests for work and exchange of scientific results should be in real-time and remove the need for manual parsing. This will accelerate cycle times and improve accuracy
Discovery projects are dynamic with partners added and removed as their expertise dictates. Provisioning and deprovisioning partners should be simple and real-time
Legal arrangements and IP ownership of project results can be complex, but copying and sharing data in email and reports makes it almost impossible to track and secure IP. All project actions should be capture in an audit trail, IP should be safeguarded during the project and easy to distribute at the end
Joint discovery projects require that partners across the network make decision together. These must be based on common views to the project data, and common analytics to ensure consistent decision making
Project managers need to have real-time access to work status and project progression. Only with this can they understand progress and make timely decision to prioritize future work
The Dotmatics solution is hosted securely in the cloud and so can be accessed by all partners outside their firewalls. Project members can be spun up and down quickly and no partner requires VPN access to another’s servers. Data and experiments can be synchronized into a company’s existing informatics applications (e.g. legacy on-premise ELN) if required
The solution provides a scientifically-aware data repository that handles molecules, sequences, assays, experiments and scientific images as well as text and data. This provides a single source of truth for each type of data within the project
Security defines each partner’s granular access to data and all partners can access all data to which they are entitled in real time.
Data can be synchronized to internal systems on a schedule or as IP is distributed at the end of a project.
The Dotmatics applications within the suite can capture experiments, molecular and biologics entities, samples and assay results directly to the shared repository. A wide range of therapeutics research is supported from small molecules to peptides to antibodies as well as conjugates and engineered biologics
Work-requesting capabilities and experiment transfers allow work to be requested from one team to another.
Shared decision support tools allow common analytics and visualizations to drive cross-team decision making.
When the Dotmatics platform is used in conjunction with Dotmatics’ BioBright solution, files can be uploaded from partners directly to a shared secure data lake. They can be automatically parsed to extract data and metadata, and validation rules can be run. Data can be then be sent automatically into ELN or assay experiments, or added directly from the lake by the ELN user later
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.
Mobile technology offers a unique opportunity to collaborate, access data and make decisions on the go, increasing throughput and reducing time consumed by review processes. The Dotmatics Platform on the cloud allows the integration of multiple, diverse systems and data sources. Organizations can now securely access all of the Dotmatics solutions, using a web browser, on their own dedicated instance running in the cloud. This provides users with an all-encompassing view of relevant information, enabling better informed science and business decisions.The Dotmatics Platform in the cloud is powered by Amazon Web Services™ (AWS). Data security is guaranteed when using the gold standard AWS infrastructure. Dotmatics’ solutions are installed in Amazon-controlled data centers around the world thus ensuring that data is housed at the user’s preferred location. The Dotmatics Platform provides a single point of access to all science data and functions across multidisciplinary groups. The flexibility enables scientists, collaborators and partners to instantly interact with the same data via the cloud regardless of location and time zone, fulfilling the promise of real time research.
At the heart of collaborative research
Protect and control your database with single tenancy
Secure access from users’ preferred device
Dotmatics Register is a web-based compound and batch registration system used to maintain corporate chemical registration and reagent databases.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
Dotmatics Reaction Workflows is a graphical environment that enables scientists to build and execute data processing workflows to perform common cheminformatics tasks, such as library enumeration, structure normalization and compound profiling. Users build workflows in a drag-and-drop environment by selecting and connecting nodes that provide inputs (e.g a list of reagents) and outputs (e.g. view in Dotmatics Vortex) or perform actions (e.g. perform a reaction), configuring them with data and then executing the workflow to produce results. Many different tasks can be configured including:
Dotmatics Chemselector manages very large chemistry datasets with fast search and trivially simple maintenance/update. It has a modern user interface focused on browsing and filtering for molecule, reagent and sample selection. The available eMolecules+ for Chemselector dataset provides access to highly curated eMolecules sourcing data.
eMolecules+ for Chemselector
Dotmatics Elemental is a chemical sketcher that enable scientists to draw, edit and save structures and reactions, and calculate properties.