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Data Evolution in Pharma: The Spread of Multimodal
Luma Antibody & Protein Engineering first in series of custom-designed multimodal solutions built on the Luma platform
The R&D landscape has shifted rapidly from small molecule therapeutics to more complicated treatments like antibodies, RNA-based medicines, cell & gene therapy, and combination treatments. Each type of therapy entails distinct yet interconnected processes, requiring scientific research organizations to handle vast and ever-expanding volumes of diverse data types that grow and evolve daily. This complexity, along with ongoing challenges of siloed data and rigid workflows, stymies R&D progress and reduces the industry's overall productivity.
Enter the Luma Antibody & Protein Engineering solution—built on key capabilities of new Geneious Luma, which is now available to purchase.
The solution streamlines antibody discovery and development, especially for monoclonal and multispecific antibodies, enabling simple integration of data, teams, and experimental phases. Powered by industry-trusted tools like Geneious and GraphPad Prism, this groundbreaking platform is transforming biologics R&D.
“The Luma Antibody & Protein Engineering solution addresses long-standing gaps in the antibody discovery workflow by providing an end-to-end process that seamlessly composes many of scientists’ favorite tools directly into Luma,” said Kalim Sailba, Chief Product Officer at Dotmatics. “Researchers can now streamline workflows from planning and in-silico design to wet lab production, validation, and data analysis, all within a unified AI-native platform.”
Working in harmony within a single platform
The new solution is built on the Dotmatics Luma scientific intelligence platform, which is designed to accelerate AI-powered data management and workflow automation by integrating data, teams, and experimental phases for researchers working on antibody discovery and other therapeutic modalities.
The solution leverages functionality from Dotmatics' best-in-breed scientific software products, allowing researchers to use familiar tools, thereby creating a more cohesive and collaborative environment without data silos. By composing these new tools within Luma, Dotmatics can offer researchers a new solution for addressing the complexities of antibody and protein engineering. That also means researchers can take advantage of the complete solution right away.
The following tools composed within Luma, will make up the Luma Antibody & Protein Engineering solution:
Geneious Luma: The first of these scientific products seamlessly composed within Luma and being introduced today is Geneious Luma. Researchers will have access to analyze and visualize DNA, RNA, and protein sequences from Geneious Prime, and the antibody discovery and screening capabilities of Geneious Biologics. They can leverage advanced bioinformatics, molecular biology, and antibody discovery capabilities of Geneious Prime and Geneious Biologics to annotate and filter sequences and to design constructs. Using Luma’s Adaptive Workflow functionality, researchers can clone constructs and express and purify proteins.
Plus, access to BioGlyph supports the design and generation of multispecific antibody formats and molecules, while running predictive machine learning models to evaluate and rank potential multispecific antibodies—letting researchers focus on the most promising candidates.
Prism uma: Use the industry-leading data analysis software, GraphPad Prism, for antibody assay development and screening. Offers native normalization and pre-processing of results prior to analysis in Prism (no Excel needed) and contextual linking between assay results, registered materials, and experimental context.
Byos and Byosphere Luma: Protein Metrics Byos offers a comprehensive package for protein characterization; analyze protein structures and behaviors with greater accuracy, then integrate these insights into predictive machine learning models to inform the next phase of synthesis. With Protein Metrics Byosphere enterprise platform you can combine biotherapeutic mass spec data, analysis, and reporting and to curate, interrogate, and share information gained in the analytical lab from Byos.
Luma Lab Connect: Streamline data collection from a wide variety of lab instruments such as flow cytometry, liquid chromatography, mass spectrometry, and additional data sources using Luma Lab Connect’s automated data ingestion. By auto-associating instrument results with the correct workflow steps, materials, and endpoint data, Luma Lab Connect mitigates a frequent manual challenge of SDMS and LIMS systems today.
Flow Luma: Evaluate the molecular properties of antibody candidates, the cells that produce them, and phenotype their therapeutic outcomes with OMIQ, the modern flow cytometry solution.
Filling critical gaps in the end-to-end workflow
Instrumentation challenges, combined with the general challenges and cost of maintaining on-premise or client-cloud solutions, ultimately result in significant IT overhead costs and time to manage, creating drastic increases in the overall time and costs of R&D. The Luma Antibody & Protein Engineering solution is designed to free up researchers to focus more on the science, and offers solutions to some of the biggest pain points our customers share with us, including:
Multimodal Registration: Versioned, entity-specific, and extensible registration models driven by linked ontologies allow for the highest levels of scientific depth and precision. Luma links these models to how scientists naturally work, so registration happens automatically and asynchronously, along with the tracking and storage of experimental and product-related information throughout the research and development process. When test results indicate a synthesized molecule does not match the design, Luma can modify the linked registered entity without losing lineage or context of the original.
Unified Results: All relevant project data—such as molecule designs, characterization data, assay data, endpoint data, and registered materials—can be correlated and unified into normalized data structures and customizable dashboards to quickly make decisions about which antibodies are best to advance. This happens automatically as people work, eliminating the need for hours of data wrangling currently implicit in activities from registration to analysis.
Customer Apps: Customers can safely extend Dotmatics Luma apps or create their own low-code apps to contextualize, flow, and correlate data from disparate sources in ways that suit their needs – with scientifically smart dashboards and visualizations to match. These apps follow industry standard SDLC processes and FAIR data principles to make getting data into and out of Luma in a governed way simple and straightforward. Data integration options include REST, GraphQL, and JDBC.
Artificial Intelligence: Luma will include significant generative and predictive ML capabilities for dry lab and wet lab tasks that customers can define and extend. Assistive GenAI will help customers accelerate the introspection, summarization, and visualization of their data. Domain-specific AI will allow Luma to leverage protein prediction, flow cytometry autogating, and other scientifically-focused models within their workflows. Composite AI will allow the use of multiple models or data sets generated from independent models to be brought together for higher order model training, selection, and execution.
Planned solutions in drug discovery…and beyond
Throughout 2025 and beyond, Dotmatics will release additional multimodal Luma solutions. The Antibody & Protein Engineering solution is the first in a new series of Luma Multimodal R&D Solutions that we’re designing to address the most urgent R&D needs.
In the coming year, we’ll roll out additional biopharma and drug discovery solutions targeted for CAR-T cell discovery, siRNA, antibody-drug conjugates (ADCs), CRISPR therapeutics, and vaccine discovery. Those solutions will include a variety of popular scientific applications including GraphPad Prism, Geneious, OMIQ , Protein Metrics, and FCS Express, each thoughtfully composed to work harmoniously within Luma. This approach allows researchers to use familiar tools while eliminating data and process silos, creating a more cohesive and collaborative environment.
Expect to see the Dotmatics Luma use case extend into broader scientific domains as well, supporting researchers across numerous industries and catalyzing collaboration. From material science and chemistry, to industrial biotech and agritech, we want to help all scientific organizations realize breakthroughs faster and with greater accuracy, so we’re working to expand the impact of this powerful combination of platform and applications. Every solution built on the Luma platform will provide a cohesive user experience along with smooth work and data flows, each delivering a scalable platform that fosters innovation.
Embrace the future of therapeutic research
Learn more about the Luma Antibody & Protein Engineering solution to see how Luma can transform your R&D processes by bridging bench science with in silico innovation.
Visit the Dotmatics blog for updates as we preview additional Luma solutions, further expanding the exciting capabilities of the Luma Scientific Intelligence Platform.
