In this white paper you will learn about an intact mass approach using the Intact workflow in Byos® that facilitates the identification, assessment, and resolution of chain shuffling in bispecific antibodies, as well as the manual validation of complex data sets using enhanced visualization tools.

• This Application Note describes an intact mass approach to investigate
  chain shuffling in bispecific antibodies.

• The Intact workflow in Byos® provides a streamlined method for
  automatic identification and assessment of bispecific antibody structure.

• The parsimonious charge deconvolution algorithm is well suited to
  resolving highly heterogeneous mixtures that result from the undesired
  matching of the antibody chains.

• Enhanced visualization tools facilitate manual inspection and validation of
  complex intact data sets.