Protein Metrics White Paper Cover

In this white paper you will learn about an intact mass approach using the Intact workflow in Byos® that facilitates the identification, assessment, and resolution of chain shuffling in bispecific antibodies, as well as the manual validation of complex data sets using enhanced visualization tools.

  • This Application Note describes an intact mass approach to investigate
    chain shuffling in bispecific antibodies.

  • The Intact workflow in Byos® provides a streamlined method for
    automatic identification and assessment of bispecific antibody structure.

  • The parsimonious charge deconvolution algorithm is well suited to
    resolving highly heterogeneous mixtures that result from the undesired
    matching of the antibody chains.

  • Enhanced visualization tools facilitate manual inspection and validation of
    complex intact data sets.