Dotmatics for Biologics Discovery

Supporting Multi-Modal Drug Discovery

Overview

Informatics with Chemistry and Biology Built in

Life science companies have greatly increased their investments in the development of a wide variety of natural biologics and chemically-modified biologics. But many struggle with how to track the processes, experiments, entities and huge volumes of data being produced, often using ad-hoc process that capture data on fileshares and in spreadsheets. The Dotmatics informatics solution for biologics discovery addresses these issues, enabling research organizations to run more successful, efficient and innovative projects. Multidisciplinary, and even cross-organization teams can capture and track all their biologics data and processes and then use the analytics and decision support capabilities to make the best-informed decisions on project progression.
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Your challenges

Do you need

Collaboration

A discovery project crosses departments, scientific disciplines, physical locations and sometimes companies. Requests, data and results need to flow seamlessly between all members to ensure the efficient execution of the project.

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Decision support

Every member of the project team needs real-time access to all the project data for which they have permission, irrespective of where it is stored. This ensures that they can make the best-informed decisions about project progression.

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Lab efficiency

Increasing efficiency will reduce discovery cycle times. This can be achieved with seamless integrated data workflows that mirror each scientist’s lab workflow, by the automation of data flows from instruments and by cross-functional workflows that span diverse team members.

Capabilites

With Dotmatics you can implement

icon Seamless multidisciplinary workflows

Biologics discovery and development workflows are complex, highly iterative and requires many handoffs between different scientific teams within a company or across collaborating organizations.

Dotmatics provides a comprehensive solution that maps on to all stages of a discovery workflow, such as the antibody discovery workflow shown (also see the Dotmatics Antibody Discovery solution).  The workflows leverage applications in the Dotmatics portfolio including a biologics-enabled electronic lab notebook (BioELN), biological registration, inventory management, assay data management, work request system, search, and visual data analytics. All Dotmatics capabilities are fully integrated allowing them to adapt seamlessly to a scientist’s workflows. For example, from the BioELN interface, a new entity in the biological registration system can be created with a single click. Scientists and managers can use the work-request system to create and monitor cross-team workflows. Dashboards allow all team members to monitor the status of project and their workflows.

icon Lab informatics for molecular biologists

Integrated workflows, created with biologics-specific ELN templates, allow molecular biologists to capture their experiments in the BioELN and send the data directly to BioregisterBioregister is the system of record that captures the full breadth of scientific datatypes that are being investigated as candidate therapeutics or used as part of the discovery process. These include DNA, RNA, proteins, antibodies, antibody-drug conjugates, plasmids, chemically-modified peptides and nucleotides, cell lines, as well as new, user-defined entities. Bioregister captures not only the entities and their attributes but also relationships between those entities. It also enables users to record sample, clone, vector, purification and expression information and to manage the protein production process. Once samples are available, scientists use Cascade to request assay services on them. Entities stored in Bioregister can be accessed directly in the BioELN, simplifying workflows.

icon Lab informatics for sample managers

Integrated workflows in Inventory allow sample managers to receive biologic (and other) samples into a hierarchy of storage locations, manage sample lifecycles, and distribute aliquots and plates for testing. RESTful web services within the Dotmatics platform means many capabilities of Inventory can be accessed directly from the BioELN, so the end-user scientist does not need to change user interface, streamlining their workflows.

icon Lab informatics for assay scientists

Integrated workflows allow assay scientists to capture and analyze data from primary, secondary and DMPK assays in Studies. Advanced visual and statistical analysis of assays is also available in Vortex.

They can publish validated assay results directly to the scientific teams.

They can use Cascade to request samples and plates from inventory management.

Studies uses the same underlying framework as the BioELN, reducing the user-interface learning curve for end-user scientists.

icon Decision support for the scientific team

All team members can use Browser to search across all research data including experiments, sequences and other biologic entities, samples and assays as soon as BioELN experiments are published and results become available.

Vortex provides bioinformatics analysis in an easy to use graphical interface that allows a wide range of scientists to undertake analyses without having to write scripts. Available methods including sequence alignment and clustering, a range of methods to assess relationships between sequence and activity and to build predictive models of those, as well as statistical analysis and high-performance visualization of project data. These capabilities allow the team to make timely, well-informed decisions about project progressions.

Real-time dashboards support project management decision making.

icon Designed for collaboration

Dotmatics software is designed for collaboration between scientific teams within an organization or, when cloud hosted, across a collaborative research network of pharmas, biotechs, CROs and academic labs. Experiments in the BioELN and published scientific data can be shared in real time, event feeds and dashboards show up-to-date project status and collaboration and communication tools facilitate interaction between distributed teams.

Products

This solution consists of

iconDotmatics Browser

Dotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.

  • Provides scientific search, such as chemical substructure and similarity.
  • Manages project level and personal search forms and views, queries, lists and reports.
  • Powerful scientific data visualization as forms, tables and charts.

iconDotmatics Vortex

Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.

  • Allows users to understand, refine and select from large and/or complex data sets
  • Allows teams to collaborate on scientific analysis through shareable workspaces and reusable templates
  • Understands numeric, textual, image, chemical structure and biologic sequence data
  • Generates high performance, interactive visualizations, including charts and tables
  • Handles very large datasets – e.g. tables of millions of compounds by thousands of descriptors or cells containing whole genome sequences
  • Has inbuilt data mining, statistical, cheminformatics and bioinformatics analysis functions
  • Loads data from many types of file or when used in conjunction with Browser, directly from databases

iconBioregister

Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides,  plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.

  • Records and manages biologic entities, including chemically-modified sequences and sequence-less entities, and associated attribute data and lineages
  • Generates chemical representation (where possible) of natural and non-natural entities
  • Determines the uniqueness of entities and assigns registration numbers, including using full chemical-based uniqueness where possible
  • Manages data associated with entity production, such as protein expression, purification and characterization
  • Records batches and samples of protein produced for the entities, with full relationship tracking

iconDotmatics Studies Notebook

Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.

  • Flexible protocols (implemented as templates) allow the single ELN to accommodate highly structured experiments such as synthetic chemistry and protein purifications, as well as more ad hoc experiment types often useful for target identification and discovery biology experiments. Ad hoc experiments are also often used to support a transition from paper based notebooks
  • Dotmatics Studies Notebook allows for collaboration on experiments by multiple scientistshttps://www.dotmatics.com/product-studies-notebook/ within or between organizations

iconDotmatics Studies

Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.

  • Defines analysis protocols for plate and non-plate based assays
  • Provides out-of-the-box and custom assay protocols, curve fit calculations, plate readers, and plate layouts captured and stored for re-use
  • Supports very high data volume assays
  • Defines business rules for very automated classification of results
  • Manual or automated processing allows screening scientists to apply the screening protocols to process raw instrument and validate the results, or experiment creation and processing to be driven via an automation layer.
  • Once completed and validated, screening results are immediately available via Browser to the project team

iconDotmatics Inventory

Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.

  • Defines a hierarchy of storage locations for an organization
  • Track samples in containers such as bottles and plates in those storage locations
  • Manages research materials, reagents and assets
  • Manages the aliquoting and dispensing workflows to distribute samples for testing
  • Maintains a full audit trail
  • Allows for searching and reporting on inventory information alongside other corporate data

iconDotmatics Platform

The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.

  • Provides the framework that supports all Dotmatics web-based scientific applications and allows them to work together to provide seamless workflows.
  • Portal for administrators to manage users and groups, applications and configurations
  • Provides APIs for automation and integration with 3rd party software
  • When used in conjunction with Dotmatics Browser provide access to data from across an organization and externally
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