Studies Notebook

Studies Notebook

A web-based Electronic Laboratory Notebook (ELN) for all scientists

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Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.

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What it does

  • Dotmatics Studies Notebook allows scientists to capture and store their experiments in a form that is easily searchable by all team members. It allows organizations to secure and audit IP and define signing workflows
  • Flexible protocols (implemented as templates) allow the single ELN to accommodate highly structured experiments such as synthetic chemistry and protein purifications, as well as more ad hoc experiment types often useful for target identification and discovery biology experiments. Ad hoc experiments are also often used to support a transition from paper based notebooks
  • Dotmatics Studies Notebook allows for collaboration on experiments by multiple scientists within or between organizations

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Benefits

  • Simple – Single intuitive framework accommodates all experiment types
  • Flexible – Protocols that define experiment types can range from highly structured forms to be filled in, to collections of drag-and-drop files
  • Scientific – Captures scientific data types (and associated files) including molecules, reactions, sequences, images, videos as well as text and numeric
  • Intelligent – Sophisticated dashboards and navigation of experiments and notebooks to quickly find relevant information and to understand organizational performance
  • Integrated –
    • Create experiments directly from a Dotmatics Cascade request
    • Register experimental results directly into chemical (Register)
      or biological (Bioregister) registration applications
    • Search data, optionally federated with data from other Dotmatics or third party databases, in Dotmatics Browser
    • Accessible – Web-based for easy deployment with no client install. Hosted on-premise or in the cloud. Browser-agnostic and available on mobile devices
  • Collaborative – Cloud-hosted deployments support external collaborations, with experiments transferable between partners
     

Key Features

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A common notebook framework for all experiments

  • Protocols define different experiment types
  • Protocols can contain:
    • Form-based data entry sections for data fields consistent to each experiment instance
    • Ad-hoc ("paper-on-glass") data entry sections to capture unique studies without having to create a new form each time
      • Drag-and-drop files directly into the ad-hoc section including office documents, PDFs, chemistry files (SD files, SMILES), sequence files (e.g., FASTA, FASTQ), images, and videos
      • Data from files (e.g., xlsx, molecules, sequences) parsed into database for powerful searching
      • In-line text and chart sections can be added at any time
  • Data secured in database and fully audited
  • Signing and countersigning workflow with notifications
  • Encrypted PDF captured and stored on completion of experiments
  • Experiment transfer between scientists for collaboration
  • Fully searchable
  • Navigation by notebook, experiment dashboards and experiment hierarchies
  • Connection to Dotmatics SDMS system allows documents/data from remote machines/instruments to be added to notebook sections
  • RESTful APIs for automation and integration of third party systems

Electronic Lab Notebook

  • Synthetic chemistry protccol
    • Enter reactions by drawing using Dotmatics Elemental or most third party drawing tools, lookup from a reaction from a previous experiment, or from a reaction database such as Reaxys (requires Reaxys license)
    • Enter or look up reagents
    • Stoichiometry table-auto-calculations and auto-naming of molecules
    • Reaction products can be registered directly from the notebook page and samples added to inventory
      • Out of the box integration to Dotmatics Register and Inventory
      • Integration to third-party registration and/or inventory systems via API
    • Write up with autotext for reagents/products/solvents etc.
    • Capture of QC data and files
    • Fully searchable reaction schemes
    • Integration with Dotmatics Reaction Workflows allow notebook experiments for library syntheses to be created directly from a library enumeration
  • Analytical chemistry protocol
    • Make and manage analytical requests
    • Manage samples
    • View analytical results

Electronic Lab Notebook

  • Preconfigured protocols are available to support the diversity of biological experimentation
    • Discovery ELN  protocol supports early-stage and investigatory biology research to simplify information capture
    • Structured protocols guide users through well-defined processes such as animal immunization and protein production and purification workflows, facilitating high quality, structured data capture
  • Tight, programmatic integration with Bioregister and Inventory mean entity definitions and resources can be accessed directly within the ELN, minimizing context-switching to other user interfaces. This streamlines workflows and minimizes disruption for scientists
    • Pull data from resources to utilize within your experiment
    • Register new entities, or log batches and samples into Inventory directly from ELN pages

chemicals & materials studies notebook example

  • Implements diverse and complex of materials research workflows - flexible and configurable protocols
    • For highly standardized workflows, configuration-driven implementation creates interfaces that 
      • Are clear, focused and transparent,
      • Minimize change management and
      • Maximize end-user adoption
    • For research innovation, ad-hoc interfaces allow researchers to capture ideas just like in a conventional lab notebook while digitally capturing and managing IP.
  • Access to relevant domain models - simplifies data capture and data management
    • Support for all chemicals industry and materials science relevant data types:
      • Synthetic chemistry, 
      • Polymers,
      • Formulations, Samples,
      • As well as analytical data and physical characterization data.  
  • Creates a platform to share knowledge and best practices
    • Supports data mining, visualization and analytics applications as part of Dotmatics' research IT platform.
    • Protocol-driven workflows create a framework to encapsulate and share best practices across an organization and increase collaborative research output.
We have found the flexibility and ease of use of the Dotmatics tools to be perfectly aligned with our project team’s needs, providing us with a unified platform from which to efficiently manage scientific dataIRBM

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