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Studies

Studies

Assay data management and analysis

Dotmatics Studies is a highly flexible,  innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.

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What it does

  • Defines analysis protocols for plate and non-plate based assays
  • Out-of-the-box and custom assay protocols, curve fit calculations, plate readers, and plate layouts captured and stored for re-use
  • Allows screening scientists to apply the screening protocols to process raw instrument and validate the results
  • Stores screening results to the Dotmatics database for search and reporting

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Benefits

  • Flexible – Designed for all types of study management
  • Screening – plate and non-plate-based assays
    • %inh, IC/EC50, KI, user-defined analysis
    • In-vivo studies using document templates
    • Kinetic studies
    • Complex assays such as ELISA, MIC, HCS
  • Integrated
    • Obtains samples and plates directly from Inventory
    • Pushes data directly to Dotmatics Vortex for advanced analytics
    • Publishes results directly to Dotmatics Browser for search and reporting
    • Creates assay experiments in Dotmatics Studies directly from Dotmatics Cascade requests
    • Shares a common framework with Dotmatics Studies Notebook to manage workflow
    • Links to Dotmatics Gateway, Register and Bioregister
  • Accessible – Web-based for easy deployment with no client install. Hosted on-premise or in the cloud
  • Collaborative -  Cloud-hosted deployments support external collaborations, such as assay execution by CROs

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Key Features

  • Supports a wide variety of assay types including HTS, HCS, dose-response, DMPK
  • Out-of-the-box set of assay templates, plate readers, plate layouts and calculations
  • Flexible protocol definitions
  • Captures custom definitions of plate readers, plate layouts and calculations for re-use in protocols
  • Captures all data related to an experiment, whether structured or unstructured
  • Structured workflow to analyze raw assay data including validation and optional  QA before publication of results
  • Curves, fits and underlying parameters are automatically stored in the database
  • Supports in-house and outsourced assays and cross company validation workflows
  • Fully integrated in the Dotmatics suite
  • Assay results published to Dotmatics Browser so they can immediately be searched in association with corporate registry and other data sources
Our company was using a rigid biology system that needed to be upgraded. When we moved to Dotmatics Studies we were surprised by the flexibility and the ease of configuration of new protocols. We didn’t have a dedicated administrator, so the support team from Dotmatics helped us from the beginning, making sure that we were able to gather and analyze our unique assay data. Now we are proficient with the system and we truly appreciate Dotmatics’ special support with the migration of data as well as the training of our team.Head of preclinical research, Biotech company, Massachussetts, US