Bioregister

Biologics entity registration, IP protection, and protein production process management

Overview

Sequence-based, chemically-modified and structureless registration

Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides,  plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.

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Features

Overview

icon What it does

  • Records and manages biologic entities, including chemically-modified sequences and sequence-less entities, and associated attribute data and lineages
  • Generates chemical representation (where possible) of natural and non-natural entities
  • Determines the uniqueness of entities and assigns registration numbers, including using full chemical-based uniqueness where possible
  • Manages data associated with entity production, such as protein expression, purification and characterization
  • Records batches and samples of protein produced for the entities, with full relationship tracking

icon Benefits

  • Centralizes and formalizes management of critically valuable research data, protecting intellectual property and improving data fidelity
  • Includes full chemical representation for natural and non-natural entities, allowing more rigorous uniqueness checking and chemistry-based search
  • Provides scientists with quick and easy bidirectional access to registration data, streamlining workflows and facilitating research. Seamlessly integrates with other Dotmatics’ applications such as Studies Notebook (ELN) and Inventory to support laboratory workflows
  • Manages all data related to biologics discovery entities, including therapeutic candidates and ancillary entities (animals, cell lines, vectors, etc.). Extensibility allows you to define new or modify existing entity definitions; create sub-types with different attributes, define custom uniqueness rules, configure workflows, and define custom monomer libraries
  • Accessibility – web-based for easy deployment with no client install. Hosted on-premises or in the cloud to support collaborations
  • Open – RESTful APIs allow Bioregister to be called as a service from third-party applications

icon Key features

Sequence management

  • Centralized registration of DNA, RNA, small peptides and proteins, including chemically-modified non-natural residues
  • Simple access to entities from the Bioregister interface, or via web services exposed in Dotmatics BrowserStudies NotebookInventory, etc., or in non-Dotmatics products
  • Ability to define custom monomer libraries with full chemistry definition, and build sequences from monomer libraries with an interactive editor
  • Integrated with the Pistoia Alliance HELM web editor to create and edit natural and non-natural sequences in HELM format
  • Keep track of entity lineage and relationships between associated entities, including entity-batch-sample hierarchies
  • Ability to create audit trail for any entity type
  • Supports implicit click chemistry reactions for biological conjugates
  • Create and register complexes from individual entities
  • Residue scan facility for fast generation of series of point-mutated sequences
  • Sequence alignment using tracked relationship to wild type sequence, or using standard (MSA) algorithms
  • Automatically calculate properties such as MW, PI and extinction coefficient
  • Handle residues/mutations in alternative numbering systems such as antibody numbering and chimeras
  • Sequence searchable using BLAST or PROSITE
  • Streamlined bulk registration workflows with automapped metadata fields

Protein production data management

  • Manage data through the whole protein production process, linked to the biological sequence
  • Prevent loss of valuable information using centralized data storage
  • Keep track of expression vectors, protein tags, expression levels, purification protocols, protein concentrations and purities
  • Customize the system to your needs and extend the data entries to be stored with each step in the protein production process
  • Store any number of documents throughout the process, including images of blots, plots and protocol descriptions