Bio Regsiter

Bioregister

Biologics entity registration and protein production process management

Dotmatics' Bioregister is a web-based application for registering sequence-based, chemically modified and structure-less biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides,  plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.

Bio Register screenshot

What it does

  • Records and manages biologic entities, including chemically-modified sequences and sequence-less entities, and associated attribute data and lineages
  • Determines the uniqueness of entities and assigns registration numbers
  • Manages data associated with entity production, such as protein expression, purification and characterization
  • Records batches and samples of protein produced for the entities

Benefits

  • Centralizes and formalizes management of critically valuable research data, protecting intellectual property and improving data fidelity
  • Provides scientists with quick and easy bidirectional access to registration data, streamlining workflows and facilitating research. Seamlessly integrates with other Dotmatics' applications such as Studies Notebook (ELN) and Inventory to support laboratory workflows
  • Manages all data related to biologics discovery entities, including therapeutic candidates and ancillary entities (animals, cell lines, vectors, etc.). Extensibility allows you to define new or modify existing entity definitions; create sub-types with different attributes, define custom uniqueness rules, configure workflows, and define custom monomer libraries
  • Accessibility – web-based for easy deployment with no client install. Hosted on-premises or in the cloud to support collaborations
  • Open – RESTful APIs allow Bioregister to be called as a service from third-party applications

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Key Features

Sequence management

  • Centralized registration of DNA, RNA, short peptides and proteins, including chemically-modified non-natural residues
  • Simple access to entities from the Bioregister interface, or via web services exposed in Dotmatics Browser, Studies Notebook, Inventory, etc., or in non-Dotmatics products
  • Ability to define custom monomer libraries with full chemistry definition, and build sequences from monomer libraries with an interactive editor
  • Keep track of entity lineage and relationships between associated entities, including entity-batch-sample hierarchies
  • Ability to create audit trail for any entity type
  • Create and register complexes from individual entities
  • Generate mutated sequences using an intuitive sequence editor
  • Residue scan facility for fast generation of series of point-mutated sequences
  • Sequence alignment using tracked relationship to wild type sequence, or using standard (MSA) algorithms
  • Automatically calculate properties such as MW, PI and extinction coefficient
  • Handle residues/mutations in alternative numbering systems such as antibody numbering and chimeras
  • Sequence searchable using BLAST or PROSITE

Protein production data management

  • Manage data through the whole protein production process, linked to the biological sequence
  • Prevent loss of valuable information using centralized data storage
  • Keep track of expression vectors, protein tags, expression levels, purification protocols, protein concentrations and purities
  • Customize the system to your needs and extend the data entries to be stored with each step in the protein production process
  • Store any number of documents throughout the process, including images of blots, plots and protocol descriptions
After testing several systems to register our biologicals we found that Bioregister was the easiest to use and configure. It has everything that we needed and it was up and running in a couple of days. The ideal system for a biotech organization. CSO, Biotech organization, England