A solid IT infrastructure is an assumed requirement for all R&D organizations. Now that digitalization has become embedded in corporate strategies such as data-driven innovation, IT organizations need to ensure that scientists have the flexibility to capture and utilize data efficiently. Scientists rarely work alone: therefore, infrastructure needs to span departments, disciplines, and geos while at the same time supporting collaborative efforts and outsourcing. These infrastructures are often exceedingly complex, either because they have grown from isolated efforts at the department level, are amalgamated through acquisitions, or are part of legacy systems that are beyond their life expectancy.
R&D IT systems come with significant associated costs, and it is the job of the IT organization to design and select the best possible infrastructure by considering all contributing fees; licensing, maintenance, deployment, customization, and implementation.
Deal with the challenges of deploying on premises, on the cloud or moving to SaaS. Support collaboration and outsourcing efforts. Consolidate vendors and avoid patchwork systems.
Minimize customizations. Implement new workflows and roles using existing infrastructure. Support data-driven research from hard-to-access data silos. Evolve systems to support new science.
Avoid rip-and-replace yet eliminate technical debt. Phase out legacy systems while providing scientists access to the data stored in them.
Dotmatics makes good on the platform promise for R&D IT, allowing you to deploy flexible, configurable workflows and roles. As it’s an open platform you can federate data sources, standardize data against a common data models, and apply security schemes that allow you to secure IP without hindering knowledge exchange and collaborations. Our platform supports these efforts via configurations, not customizations, resulting in an infrastructure that is easier to maintain and service.
The Dotmatics platform can be deployed on prem, in private cloud, or as a SaaS infrastructure. Since each scenario utilizes the same codebase, you are never locked into a specific deployment scenario which means your infrastructure is future-proofed for company changes in direction such as a move from on-prem to the cloud or vice versa. Upgrades are greatly simplified since Dotmatics supports all customers via configurations of a single code base, not customizations.
While many organizations are increasingly trying to move IT infrastructure into the cloud, options for R&D IT are limited, creating unique challenges in terms of interoperability, scalability, availability, and latency.
Dotmatics solves this problem with the option to run a Dotmatics supported AWS instance as a SaaS system. We have over 8 years of AWS presence, run over 300 single-tenant customer instances, manage 180+ TB of data. More than half of our new customers choose to run their systems as SaaS configurations.
One of the major challenges in R&D IT is how to support complex scientific data and application requirements. Whether companies respond by allowing individual departments to pick “best-of-breed” applications, or engaging in customization projects, the burden for IT departments is generally considerable.
Within the Dotmatics platform, applications have access to all connected data sources, native Dotmatics, in-house developed, or third-party – including web sources. The application tier also allows connections to third-party applications to allow for integrated workflows and seamless data exchange.
R&D IT infrastructures are rarely designed from scratch but need to find strategies to deal with legacy applications and data. Even if technically feasible, a rip-and-replace strategy can create serious change management challenges.
The Dotmatics platform solves these challenges by putting a data intelligence infrastructure on top of existing systems. This federates and contextualizes scientific data and to support scientific data mining and data-driven R&D, including machine learning (ML) and artificial intelligence (AI) applications. Data federation also allows IT departments to implement systems that help smoothing out transitions from legacy systems to modern infrastructure.
By its nature, science is ever evolving. Consequently, scientists will always require new functionality and data access options to be incorporated into their R&D IT systems.
Dotmatics was founded on the idea that scientists should have access to all of their data, all the time. Data federation and data visualization are core components of our strategy, complemented with a full suite of lab automation and role-based workflow capabilities. We partner with our customers to continuously innovate, recent examples include metadata frameworks, entity creation/registration for biologics and non-specific entities, support for multiple assays within a single experiment as well as graph analysis for mining reaction pathway information.
Dotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.
The Dotmatics Platform on the cloud allows the integration of multiple, diverse systems and data sources. Organizations can now securely access all of the Dotmatics solutions, using a web browser, on their own dedicated instance running in the cloud. This provides users with an all-encompassing view of relevant information, enabling better informed science and business decisions. The Dotmatics Platform in the cloud is powered by Amazon Web Services™ (AWS). Data security is guaranteed when using the gold standard AWS infrastructure. Dotmatics’ solutions are installed in Amazon-controlled data centers around the world thus ensuring that data is housed at the user’s preferred location. The Dotmatics Platform provides a single point of access to all science data and functions across multidisciplinary groups. The flexibility enables scientists, collaborators and partners to instantly interact with the same data via the cloud regardless of location and time zone, fulfilling the promise of real time research.
What it does:
At the heart of collaborative research
Protect and control your database with single tenancy
Secure access from users’ preferred device
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
Dotmatics Chemselector manages very large chemistry datasets with fast search and trivially simple maintenance/update. It has a modern user interface focused on browsing and filtering for molecule, reagent and sample selection. The available eMolecules+ for Chemselector dataset provides access to highly curated eMolecules sourcing data.
eMolecules for Chemselector
Dotmatics for Office makes Microsoft™ Office® applications such as Excel®, PowerPoint®, Word, OneNote and Outlook® chemically aware.
Dotmatics Elemental is a chemical sketcher that enable scientists to draw, edit and save structures and reactions, and calculate properties.
Dotmatics Gateway is a scientific document management solution that serves as a central place to share project documents and associated information across an internal or externalized team. It provides discussion threads and project events feeds.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Nucleus is a straightforward solution for importing flat files, such as spreadsheets, into a database.
Easily upload data from a variety of sources ready for query and reporting in Dotmatics Browser.
Dotmatics Pinpoint is a chemical cartridge for indexing and searching chemistry within Oracle databases.
Pinpoint enables indexing of chemical structures, calculations of physical chemical properties and substructure searches within an Oracle database. It is used to support structure searching with Dotmatics Browser, check for structural uniqueness and register molecules in Dotmatics Register, and store and search chemical reactions in Dotmatics Studies Notebook.
Reaction Workflows is a graphical environment that enables scientists to build and execute data processing workflows to perform common cheminformatics tasks, such as library enumeration, structure normalization and compound profiling. Users build workflows in a drag-and-drop environment by selecting and connecting nodes that provide inputs (e.g a list of reagents) and outputs (e.g. view in Dotmatics Vortex) or perform actions (e.g. perform a reaction), configuring them with data and then executing the workflow to produce results. Many different tasks can be configured including:
Dotmatics Register is a web-based compound and batch registration system used to maintain corporate chemical registration and reagent databases.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.