Development of chemically-modified therapeutics requires an understanding of both chemistry and biology. Cross functional teams need a variety of ad hoc and standardized workflows to effectively capture all project data.
Chemically-modified therapeutics discovery projects generate large volumes of diverse data. This creates challenges in managing the data, especially tracking relationships between candidates. Viewing all project data in context is critical for informed decision-making.
Competition in the bio-pharma industry is fierce. Many companies are targeting the same therapeutic areas. Scientific innovation in novel therapeutics design and experimental processes are valuable assets. They need rigorous protection.
Included in this definition are antibody-drug conjugates (ADCs), peptide-drug conjugates (PDCs), antisense oligonucleotides (asRNA), small interfering RNA (siRNA), modified RNA (modRNA), stapled peptides, and cyclic and bicyclic peptides. This is clearly a diverse set of molecules, varying greatly in size and composition, but the common feature of being chemically-modified creates significant challenges for most scientific informatics systems. These systems are built to handle either chemistry or biology data, but rarely can they manage both. This causes significant barriers for the cross-functional teams that typically work on developing these novel therapeutics.
Systems that support only chemistry or biology can’t capture the full scientific definition and information for chemically-modified therapeutics, undermining this research and weakening intellectual property (IP) protections. Collaborations between chemists and biologists are hindered, slowing project progress. In some cases, organizations will adopt two informatics systems, one for biology data and one for chemistry data. This is also sub-optimal because the fidelity of the entity definitions across the systems cannot be guaranteed. Data integration becomes difficult, again undermining IP protections, data quality and cross-functional team collaboration.
The Dotmatics solution for chemically-modified therapeutics provides the scientific rigor needed to completely capture the full detail of these entities and delivers the broad set of informatics capabilities to fully support your project goals. The Dotmatics Platform inherently understands both chemistry and biology, to ensure that project data is captured and managed by a single source of truth. This ensures that IP protection is maintained, data quality is at its highest, and cross-functional teams of scientists can collaborate efficiently and effectively.
The core of the Dotmatics solution for chemically-modified therapeutics is Bioregister, our biological registration system that generates a full chemical representation of sequence-based entities, using InChI keys. Users can easily transition between sequence and molecular views, or simply use whatever makes most sense to them, as a chemist or a biologist. The full chemical representation is used for uniqueness checking, and chemistry-based searching can be performed. Bioregister also generates HELM notations for these entities, which is often useful for communicating with strategic partners. Bioregister can create implicit bioconjugation linkages based on “click chemistry”, to streamline the definition and capture of ADCs and PDCs.
Supporting Bioregister, Dotmatics provides many other modules as part of the Platform. Studies Notebook, the Dotmatics Electronic Lab Notebook (ELN) is build to be flexible, allowing templates to be configured to support chemistry or biology-based workflows. If you’re doing more investigational experiments, those are supported too with a simple Discovery ELN template. Vortex, our advanced analysis and visualization application includes advanced algorithms for chemistry and biology analyses, and can display chemically modified therapeutics in either molecular or sequence format. And ultimately, Dotmatics Browser is the key tool allowing scientists of all types to search, browse and view their data, and make well-informed decisions that accelerate their research and innovation.
Dotmatics Browser is a powerful web-based search and reporting solution that provides federated searching across Dotmatics and third party research databases, enabling research scientists to access all of their data whenever they need it, irrespective of where it is stored.
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides, plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.