Dotmatics is a leading global scientific informatics software and services provider, delivering solutions tailored to the modern, highly collaborative and mobile scientific environments.
Dotmatics Platform 2020.1* is now available and contains major enhancements to Browser, Studies, Studies Notebook and Reaction Workflows.
A project to update the look and feel of Browser has been underway over the last two releases. The aim is to both modernize the user interface and also to harmonize across the suite to provide a consistent experience for users of Browser, the ELN and other web applications. The new Browser framework, menus and forms updates were rolled out in version 5.5. In 2020.1 there are two major new UI updates
The 2020.1 release includes the capability to perform a sequence alignment search in Browser. The search uses a BLAST-like algorithm that has been available in Vortex for some time and works with both nucleic acid and protein sequences. More than simply performing pattern-matching on residues, the search algorithm takes into account the physicochemical similarity of residue side chains (using a BLOSUM matrix) at a given sequence position when finding and ranking search results.
Additional metadata, such as alignment length and score are provided. These metrics can also be used to condition the search. Search results can be exported to be used in other applications.
Screening Ultra is Dotmatics next generation solution for assay data management designed to support the latest assay science, huge data volumes and advances in lab and data automation. It was first released in 5.5 with support for HTS and dose response assays, and was then expanded in a 5.5 mid-cycle release to add kinetic and multiplex assay types.
In 2020.1 there are significant enhancements applicable to all assay types including
In 2020.1 we have introduced a much more streamlined way to edit office documents that are stored in the ELN. Once any office document (Word, Powerpoint, Excel) is loaded into the ad-hoc section of the ELN, it can be opened for editing directly from the ELN entry. All changes to the document are captured back to the ELN each time the document is saved.
Reaction Workflows allows chemists to design and enumerate libraries. If these are virtual design libraries, they can be sent to Blueprint (via a new Blueprint node in 2020.1) or Vortex for further analysis and filtering.
For libraries planned for synthesis, 2020.1 includes new capabilities to better support the ability to automatically create the experiment(s) in the Studies Notebook that will be needed to synthesize the library. A new parallel synthesis template is included in the default ELN configuration. This handles the array of reactants send from reaction workflows, which can set the reagent group that will be the rate limiting. It also displays each individual reaction. Two way interaction allows for the design to be amended in reaction workflows (e.g. a new reagents added) and the corresponding ELN pages be updated automatically.
Dotmatics Launcher is a new utility that can be installed on client desktops to facilitate the launch of desktop applications and their interaction with the Dotmatics web applications. In 2020.1 this is used to launch Dotmatics Vortex, approved third-party chemical sketcher applications including ChemDraw, Biovia Draw and Marvin, and Microsoft Office® office documents. Launcher is highly secure, using public key cryptography to sign files and commands and replaces legacy Java Webstart methods. For end-users this provides a much simpler and more seamless interaction as is evidenced by the example shown above editing a word document within the ELN.
*A word on release numbering: Dotmatics products have previously each had an independent numbering scheme – for example the last two platform releases were 5.4 and 5.5, while the last two Bioregister releases were 3.1 and 3.2. To provide greater consistency, all Dotmatics releases will now follow the same format with a release year and release version within that year, hence this release is Platform 2020.1 being the first release of Platform in 2020, rather than 5.6 as it would previously have been.