Life science companies have greatly increased their investments in the development of a wide variety of natural biologics and chemically-modified biologics. But many struggle with how to track the processes, experiments, entities and huge volumes of data being produced, often using ad-hoc process that capture data on fileshares and in spreadsheets. The Dotmatics informatics solution for biologics discovery addresses these issues, enabling research organizations to run more successful, efficient and innovative projects. Multidisciplinary, and even cross-organization teams can capture and track all their biologics data and processes and then use the analytics and decision support capabilities to make the best-informed decisions on project progression.
Seamless Multidisciplinary Workflows
Biologics discovery and development workflows are complex, highly iterative and requires many handoffs between different scientific teams within a company or across collaborating organizations.
Dotmatics provides a comprehensive solution that maps on to all stages of a discovery workflow, such as the antibody discovery workflow shown (also see the Dotmatics Antibody Discovery solution). The workflows leverage applications in the Dotmatics portfolio including a biologics-enabled electronic lab notebook (BioELN), biological registration, inventory management, assay data management, work request system, search, and visual data analytics. All Dotmatics capabilities are fully integrated allowing them to adapt seamlessly to a scientist's workflows. For example, from the BioELN interface, a new entity in the biological registration system can be created with a single click. Scientists and managers can use the work-request system to create and monitor cross-team workflows. Dashboards allow all team members to monitor the status of project and their workflows.
Lab Informatics for Molecular Biologists
Integrated workflows, created with biologics-specific ELN templates, allow molecular biologists to capture their experiments in the BioELN and send the data directly to Bioregister. Bioregister is the system of record that captures the full breadth of scientific datatypes that are being investigated as candidate therapeutics or used as part of the discovery process. These include DNA, RNA, proteins, antibodies, antibody-drug conjugates, plasmids, chemically-modified peptides and nucleotides, cell lines, as well as new, user-defined entities. Bioregister captures not only the entities and their attributes but also relationships between those entities. It also enables users to record sample, clone, vector, purification and expression information and to manage the protein production process. Once samples are available, scientists use Cascade to request assay services on them. Entities stored in Bioregister can be accessed directly in the BioELN, simplifying workflows.
Lab Informatics for Sample Managers
Integrated workflows in Inventory allow sample managers to receive biologic (and other) samples into a hierarchy of storage locations, manage sample lifecycles, and distribute aliquots and plates for testing. RESTful web services within the Dotmatics platform means many capabilities of Inventory can be accessed directly from the BioELN, so the end-user scientist does not need to change user interface, streamlining their workflows.
Lab Informatics for Assay Scientists
Integrated workflows allow assay scientists to capture and analyze data from primary, secondary and DMPK assays in Studies. Advanced visual and statistical analysis of assays is also available in Vortex.
They can publish validated assay results directly to the scientific teams.
They can use Cascade to request samples and plates from inventory management.
Studies uses the same underlying framework as the BioELN, reducing the user-interface learning curve for end-user scientists.
Decision Support for the Scientific Team
All team members can use Browser to search across all research data including experiments, sequences and other biologic entities, samples and assays as soon as BioELN experiments are published and results become available.
Vortex provides bioinformatics analysis in an easy to use graphical interface that allows a wide range of scientists to undertake analyses without having to write scripts. Available methods including sequence alignment and clustering, a range of methods to assess relationships between sequence and activity and to build predictive models of those, as well as statistical analysis and high-performance visualization of project data. These capabilities allow the team to make timely, well-informed decisions about project progressions.
Real-time dashboards support project management decision making.
Designed for Collaboration
Dotmatics software is designed for collaboration between scientific teams within an organization or, when cloud hosted, across a collaborative research network of pharmas, biotechs, CROs and academic labs. Experiments in the BioELN and published scientific data can be shared in real time, event feeds and dashboards show up-to-date project status and collaboration and communication tools facilitate interaction between distributed teams.
Morphosys, a leader in the field of therapeutic antibodies users Vortex’s biologics capabilities to support analysis of molecules in their antibody research and to analyze and visualize their screening data enabling rapid, informed decision-making.
One of the world’s largest biotech companies uses the solution to automate the analysis of intact protein mass spectral data for complex antibody-drug conjugates. Replacing a manual labor-intensive and error-prone Excel-based process saved them significant time and cost, and greatly increased throughput by removing a processing bottleneck whilst minimizing manual errors.
A European biotech developing antibodies for immuno-oncology converted their entirely ad-hoc Excel-based system, which had become unmanageable, into a single managed system using the Dotmatics suite for biological registration, assay data management, searching, visualization and analysis.