キメラ抗原受容体T細胞(CAR-T)療法は、生物学的製剤開発の新しい分野です。この治療法は、様々な形態のがんを標的とし、「生きた治療法」として作用します。患者自身のTリンパ球細胞を利用する個別化医療のひとつです。
CARsは人工的な受容体タンパク質で、ほとんどが天然のサブドメインで構成されています。この治療法を研究している科学者は、実験室でのデータ管理に多くの課題を抱えています。
サイトカイン放出症候群のような副作用を回避するため、タンパク質を正確に定義し、その完全な化学記述を捉えることは、知的財産(IP)保護のために非常に重要です。また、サブドメインと関連するエンティティ間の関係を追跡することも不可欠です。このような複雑なワークフローには、柔軟性があり標準化されたソリューションが必要です。また、科学者は十分な情報に基づいた迅速な意思決定を行うために、すべてのデータをリアルタイムで確認する必要があります。
CAR-Tの研究では、実験の計画と実行の繰り返しが必要です。研究が進むにつれて、実験はアドホックなものから標準化されたワークフローへと移行します。
CAR-Tの研究では、さまざまな前駆体タンパク質から多くの候補分子が生まれます。CARsとそのサブドメイン間の関係を追跡することは重要で、その情報はいつでも入手できるようにしておく必要があります。
CAR-Tの研究では、抗原結合と細胞応答の適切な組み合わせを持つ新規のCARsを設計し、その貴重な研究データを保護する必要があります。
Dotmatics’ Bioregister is a web-based application for registering sequence-based, chemically-modified and structureless biological entities, allowing biologics discovery organizations to ensure entity uniqueness and protect their intellectual property. Bioregister supports management of a broad set of biologics entities, including DNA, RNA, peptides and proteins, antibodies, conjugates, non-natural peptides and nucleotides, plasmids, cell lines and user-defined entities. It also enables users to record batches and samples for these entities, purification and expression information, and other protein production data.
Dotmatics Studies Notebook is an Electronic Laboratory Notebook (ELN) with flexible templating to capture, store and search experiments from all scientific disciplines.
Dotmatics Browser provides a comprehensive view of project data
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
Mobile technology offers a unique opportunity to collaborate, access data and make decisions on the go, increasing throughput and reducing time consumed by review processes. The Dotmatics Platform on the cloud allows the integration of multiple, diverse systems and data sources. Organizations can now securely access all of the Dotmatics solutions, using a web browser, on their own dedicated instance running in the cloud. This provides users with an all-encompassing view of relevant information, enabling better informed science and business decisions.The Dotmatics Platform in the cloud is powered by Amazon Web Services™ (AWS). Data security is guaranteed when using the gold standard AWS infrastructure. Dotmatics’ solutions are installed in Amazon-controlled data centers around the world thus ensuring that data is housed at the user’s preferred location. The Dotmatics Platform provides a single point of access to all science data and functions across multidisciplinary groups. The flexibility enables scientists, collaborators and partners to instantly interact with the same data via the cloud regardless of location and time zone, fulfilling the promise of real time research.
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