Dotmatics’ solutions support small molecule discovery from hit and lead identification, through lead optimization, to candidate selection. Fully integrated laboratory informatics capabilities capture instrument data, experiments, molecules, samples and assays. Decision support tools enable gathering, analysis and visualization of project data. Together, these help project teams be more efficient and make better informed decisions faster.
A discovery project crosses departments, scientific disciplines, physical locations and sometimes companies. Requests, data and results need to flow seamlessly between all members to ensure the efficient execution of the project.
Every member of the project team needs real-time access to all the project data for which they have permission, irrespective of where it is stored. This ensures that they can make the best-informed decisions about project progression.
Increasing efficiency will reduce discovery cycle times. This can be achieved with seamless integrated data workflows that mirror each scientist’s lab workflow, by the automation of data flows from instruments and by cross-functional workflows that span diverse team members.
All team members can search across all research data including experiments, molecules, samples and assays as soon as results become available. Cheminformatics analysis and high-performance visualization of project data enable the team to make well-informed decisions about project progressions. Compound designers can use molecule and library design tools to propose new molecules. Real-time dashboards support project management decision making.
Dotmatics’ software is designed for collaboration between scientific teams within an organization or, when cloud hosted, across a collaborative research network of pharmas, biotechs, CROs and academic labs. Scientific data can be shared in real time, event feeds and dashboards show up-to-date project status, and collaboration and communication tools facilitate interaction between distributed teams.
Find out more about how you can use Dotmatics to improve your collaboration:
Dotmatics lab data automation platform can greatly increase the efficiency of the lab. Data can be gathered from instruments and securely stored in a data lake. It is then parsed to extract data and meta-data and validation can be performed. The data can then be sent directly to the lab notebook or assay data management systems. All this can happen in real-time and without human intervention. This frees up valuable scientists time from mundane data gathering and processing tasks. It eliminates human-error, ensuring that data is clean and comprehensive when used to drive AI/ML models, or directly in scientists’ decision making.
Dotmatics Vortex is an interactive data visualization and analysis solution for scientific decision support. Building on and extending the spreadsheet paradigm, it provides the data manipulation, statistical analysis and sophisticated plotting capabilities required to explore and understand any complexity and size of data. Vortex is also scientifically aware providing native cheminformatics and bioinformatics analysis and visualizations.
The Dotmatics Platform is the common framework that supports the Dotmatics web-based scientific applications and allows them to work together to provide users seamless end-to-end workflows. The Platform supports managed deployments in the Cloud or self-supported deployments on premise. An open architecture enables workflows to include third-party software integration. When used together with Dotmatics Browser the Platform allows federated data access across corporate and external research data.The Dotmatics Platform is completely unified – it provides common data models, code and architecture to support business workflows that span the capabilities of the individual applications. This is important for enterprise enablement of research organizations, providing ease of maintenance and development. It gives the lowest possible total cost of ownership compared to platforms that support their applications with less tightly integrated collections of multiple technologies and/or architectures with multiple development histories.
Blueprint is a web-based visualization and scientific analytics application. It is designed to help project scientists working on small molecule discovery projects to visualize and analyze their data, and to help them to design their next set of compounds to make.
Dotmatics Chemselector manages very large chemistry datasets with fast search and trivially simple maintenance/update. It has a modern user interface focused on browsing and filtering for molecule, reagent and sample selection. The available eMolecules+ for Chemselector dataset provides access to highly curated eMolecules sourcing data.
eMolecules+ for Chemselector
Dotmatics Cascade manages the requesting and assignment of laboratory tasks, and tracking the progression of samples, across multiple teams within an organization or across a collaborating network.
Dotmatics Studies is a highly flexible, innovative screening data management solution to capture and analyze all types of screening experiments from high content (HCS) and high throughput (HTS) to dose-response and DMPK studies.
Dotmatics Reaction Workflows is a graphical environment that enables scientists to build and execute data processing workflows to perform common cheminformatics tasks, such as library enumeration, structure normalization and compound profiling. Users build workflows in a drag-and-drop environment by selecting and connecting nodes that provide inputs (e.g a list of reagents) and outputs (e.g. view in Dotmatics Vortex) or perform actions (e.g. perform a reaction), configuring them with data and then executing the workflow to produce results. Many different tasks can be configured including:
Dotmatics Inventory is a fully searchable sample and materials inventory that tracks chemicals, biologics, instruments and associated data across a hierarchy of locations and manages the dispensing and plating workflows, as samples are moved through an R&D process.
Dotmatics Pinpoint is a chemical cartridge for indexing and searching chemistry within Oracle databases.
Pinpoint enables indexing of chemical structures, calculations of physical chemical properties and substructure searches within an Oracle database. It is used to support structure searching with Dotmatics Browser, check for structural uniqueness and register molecules in Dotmatics Register, and store and search chemical reactions in Dotmatics Studies Notebook.
Dotmatics Elemental is a chemical sketcher that enable scientists to draw, edit and save structures and reactions, and calculate properties.
Dotmatics Register is a web-based compound and batch registration system used to maintain corporate chemical registration and reagent databases.